On September 17, 2021, Jiang, Meifen; Liu, Minjie; Yu, Chao; Cheng, Dang; Chen, Fener published an article.Computed Properties of 517-23-7 The title of the article was Fully Continuous Flow Synthesis of 3-Chloro-4-oxopentyl Acetate: An Important Intermediate for Vitamin B1. And the article contained the following:
A fully continuous flow synthesis of 3-chloro-4-oxopentyl acetate, an important intermediate for vitamin B1, was developed. This continuous flow manufacturing included two chem. transformations and an inline extraction step without intermediate purification and solvent exchange. In this work, the traditional synthetic route for batch operation was efficiently simplified via a series of separated screening tests in flows under various conditions. The authors found that the chlorination reaction can be carried out in only 30 s at room temperature by flow. The decarboxylation/acylation step was also simplified by using a cross-mixer, so that acetic anhydride was no longer required in the acylation reaction. A computational fluid dynamics simulation was carried out to study the improved micromixing of liquid-liquid two-phase streams. Finally, 3-chloro-4-oxopentyl acetate was obtained in a 90% isolated yield with a product purity of 96% and a total residence time of approx. 32 min. This fully continuous process was operated smoothly for 12 h, and approx. 19.1 g of the desired product was generated with a production rate of 1.79 g h-1. The experimental process involved the reaction of 3-Acetyldihydrofuran-2(3H)-one(cas: 517-23-7).Computed Properties of 517-23-7
The Article related to chlorooxopentyl acetate preparation vitamin b1 intermediate continuous flow, Aliphatic Compounds: Esters, Linear Anhydrides, Acyl Peroxides, and Acyl Halides and other aspects.Computed Properties of 517-23-7
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics