On June 6, 2012, Han, Haitao; Pan, Jianfeng; Jiang, Zhigan; Hu, Tao; Ma, Rujian; Chen, Shuhui published a patent.Application In Synthesis of tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate The title of the patent was A process for preparing diazabicyclo[3.3.1]nonane derivatives. And the patent contained the following:
The invention relates to a process for the preparation of diazabicyclo[3.3.1]nonane derivative I, useful as intermediate for manufacturing antiarrhythmic drugs. For instance, the compound I was prepared by heterocyclization of N-Boc-4-oxopiperidine with formaldehyde and benzylamine followed by addition to 1-[(isocyanomethyl)sulfonyl]-4-methyl-benzene, hydrolysis, protection with (Boc)2O, reduction, and protection with CbzCl. The experimental process involved the reaction of tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate(cas: 227940-70-7).Application In Synthesis of tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate
The Article related to diazabicyclononane derivative preparation antiarrhythmic intermediate, Heterocyclic Compounds (More Than One Hetero Atom): Eight- and Higher-Membered Rings and other aspects.Application In Synthesis of tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics