On March 20, 2013, Zhao, Baoli; Cheng, Kai; Hu, Liujiang published a patent.COA of Formula: C11H11NO2 The title of the patent was Preparation of arylenealkyne substituted indolizine derivatives as antitumor agents. And the patent contained the following:
This patent supplies chem. structural formula I of title arylenealkyne indolizine derivatives, in which R1 is H or halogen atom, R2 is cyano, COOEt or COOBu, and R3 is C1-C4 alkyl. 3-[2-(4-Chlorophenyl)ethynyl]-1-indolizinecarbonitrile (II) was prepared by reacting 4-chloro-2,2-dibromovinylbenzene and 1-indolizinecarbonitrile in the presence of inorganic alkali and Pd catalyst in N,N-DMF under nitrogen protection at 80-100°C, and separating and purifying. Compound II was prepared and showed IC50 value of 3.2 μm/mL against colon cancer cells. The arylenealkyne substituted indolizine derivatives are applied for producing antineoplastic drug. The experimental process involved the reaction of Ethyl indolizine-1-carboxylate(cas: 93476-46-1).COA of Formula: C11H11NO2
The Article related to indolizine arylenealkyne preparation antitumor, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.COA of Formula: C11H11NO2
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics