On January 10, 2008, Cook, Anthony; McInally, Tom; Thom, Stephen; Wada, Hiroki published a patent.Name: Methyl 2-(3-formylphenyl)acetate The title of the patent was Preparation of 8-oxoadenine derivatives as modulators of TLR7. And the patent contained the following:
8-Oxoadenine derivatives of formula I [A = aryl, heteroaryl; R1 = H, OH, alkoxy, aryl, cycloalkyl, etc.; Y1-Y3 = bond, alkylene; X1 = bond, O, S, SO2, (substituted) NH; Z1 = alkylene, cycloalkylene; R2 = H, alkyl, cycloalkyl, etc.; R3 = alkyl, hydroxyalkyl, alkoxy, (substituted) amino, etc.; R4 = (substituted) CO2H, SO2NH2, acyl, etc.; n = 0-2] are prepared The 8-oxoadenine derivatives act as modulators of Toll-like Receptor (TLR) 7 and thus may be used in the treatment of asthma, hepatitis, allergic diseases, viral and bacterial infection as well as cancer. Thus, II was prepared, and had pMEC > 7.7 in human TLR7 assay. The experimental process involved the reaction of Methyl 2-(3-formylphenyl)acetate(cas: 142327-44-4).Name: Methyl 2-(3-formylphenyl)acetate
The Article related to oxoadenine preparation tlr7 modulator, Biomolecules and Their Synthetic Analogs: Others, Including Purines, Pyrimidine Nucleic Acid Bases, Flavins, Lignans and other aspects.Name: Methyl 2-(3-formylphenyl)acetate
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