Heckenbichler, Kathrin; Schweiger, Anna; Brandner, Lea Alexandra; Binter, Alexandra; Toplak, Marina; Macheroux, Peter; Gruber, Karl; Breinbauer, Rolf published an article in 2018, the title of the article was Asymmetric Reductive Carbocyclization Using Engineered Ene Reductases.Application of 517-23-7 And the article contains the following content:
Ene reductases from the Old Yellow Enzyme (OYE) family reduce the C=C double bond in α,β-unsaturated compounds bearing an electron-withdrawing group, for example, a carbonyl group. This asym. reduction has been exploited for biocatalysis. Going beyond its canonical function, we show that members of this enzyme family can also catalyze the formation of C-C bonds. α,β-Unsaturated aldehydes and ketones containing an addnl. electrophilic group undergo reductive cyclization. Mechanistically, the two-electron-reduced enzyme cofactor FMN delivers a hydride to generate an enolate intermediate, which reacts with the internal electrophile. Single-site replacement of a crucial Tyr residue with a non-protic Phe or Trp favored the cyclization over the natural reduction reaction. The new transformation enabled the enantioselective synthesis of chiral cyclopropanes in up to >99 % ee. The experimental process involved the reaction of 3-Acetyldihydrofuran-2(3H)-one(cas: 517-23-7).Application of 517-23-7
The Article related to ene reductase opr3 yqjm asym reductive carbocyclization chiral cyclopropane, c−c-bond formation, asymmetric synthesis, biocatalysis, enoate reductases, protein engineering and other aspects.Application of 517-23-7
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics