On April 13, 1988, Morimoto, Akira; Noguchi, Noryoshi published a patent.Computed Properties of 53838-27-0 The title of the patent was Preparation of 2-oxoazetidin-1-yl- and 2-oxopyrrolidin-1-yl-5-oxotetrahydrofuran-2-carboxylic acid derivatives as antibacterials. And the patent contained the following:
β-Lactams and 4-butanelactams [I; R1 = NH2, N-bonded organic group; R2 = CO2H or its derivative; n = 1,2] and salts thereof, useful as antibacterials (no data), were prepared Treatment of 2-[(2S)-2-(benzyloxycarbonylamino)-4-hydroxybutyryl]amino-2-(methylthio)glutaric acid 1-4-nitrobenzyl 5-tert-Bu diester (preparation given) with CF3CO2H containing anisole under ice-cooling for 80 min followed by Hg(OAc)2 in DMF at -50 to -20° for 20 min gave 2-[(2S)-2-(benzyloxycarbonylamino)-4-hydroxybutyryl]amino-5-oxotetrahydrofuran-2-carboxylic acid 4-nitrobenzyl ester which was cyclized by treatment with Ph3P and EtO2CN:NCO2Et in THF to give 2-[(3S)-3-(benzyloxycarbonylamino)-2-oxopyrrolidin-1-yl]-5-oxotetrahydrofuran-2-carboxylic acid 4-nitrobenzyl ester. The experimental process involved the reaction of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate(cas: 53838-27-0).Computed Properties of 53838-27-0
The Article related to oxoazetidinyloxotetrahydrofurancarboxylate preparation antibacterial, oxopyrrolidinyloxotetrahydrofurancarboxylate preparation antibacterial, beta lactam preparation antibacterial and other aspects.Computed Properties of 53838-27-0
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