On March 31, 2022, Zhang, Yan; Yu, Yiping; Li, Hong; Huang, Wenge; Wang, Ping published an article.Product Details of 85-91-6 The title of the article was Effects of Citri Reticulatae Pericarpium and grapefruit juice on the pharmacokinetics of omeprazole in rats. And the article contained the following:
The effects of Citri Reticulatae Pericarpium (CRP) and grapefruit juice (GFJ) on the pharmacokinetics of omeprazole were investigated in this study. Sprague-Dawley rats were pretreated with CRP decoction or GFJ for 28 consecutive days. After a single intragastric administration of 6.0 mg/kg, the concentration of omeprazole in the plasma was determined by high-performance liquid chromatog. (HPLC), and the pharmacokinetic parameters were calculated by Kinetica software 5.0. A high-performance liquid chromatog.-quadrupole-time-of-flight mass spectrometry (HPLC-Q-TOF-MS) method was established to identify the chem. components in CRP decoction and GFJ. The results showed that the AUCt-∞ was significantly increased when coadministrated with CRP. The AUC0-t and AUC0-∞ was remarkably increased; the Cl was decreased when coadministrated with GFJ. A total of 31 and 28 bioactive compounds were identified in the CRP decoction and GFJ, resp. Flavonoids and furanocoumarins, including hesperidin, hesperetin, naringenin, sinensetin, tangeretin, nobiletin, and 6′,7′-dihydroxybergamottin, were simultaneously identified in CRP decoction and GFJ. This study indicates that the increased bioavailability of omeprazole may be due to the inhibition of hepatic cytochrome P 450 enzymes, and the systemic exposure should be monitored when concomitant administration with CRP and GFJ. Citri Reticulatae Pericarpium (CRP) has been widely consumed as a daily condiment, functional food, and a traditional Chinese medicine. Omeprazole, primary metabolized by CYP450 enzymes, was usually coadministered with CRP for the treatment of gastrointestinal disease. Studies have confirmed that much fruit juices, including grapefruit juice, may affect drug metabolism enzymes. CRP and grapefruit (Citrus paradisi Macf.) belong to the genus Citrus and family Rutaceae with different species. Therefore, the pharmacokinetic interaction of CRP decoction and grapefruit juice with omeprazole is worthy of attention. The results of this study can provide basic pharmacol. data support for the safe and effective clin. use of omeprazole. It can also provide a theor. basis for the development of new functional products and daily application of CRP. The experimental process involved the reaction of Methyl N-Methylanthranilate(cas: 85-91-6).Product Details of 85-91-6
The Article related to citri reticulatae pericarpium grapefruit juice omeprazole pharmacokinetics effect, citri reticulatae pericarpium, grapefruit juice, herb-drug interaction, omeprazole, pharmacokinetics and other aspects.Product Details of 85-91-6
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