On February 14, 2009, Gellerman, Gary; Hazan, Eran; Kovaliov, Marina; Albeck, Amnon; Shatzmiler, Shimon published an article.Related Products of 53838-27-0 The title of the article was Synthesis of orthogonally protected optically pure ketopiperazine, diketopiperazine, ketodiazepane, and 3-aminopyrrolidone building blocks for peptidomimetic combinatorial chemistry. And the article contained the following:
A simple and convenient synthesis of orthogonally protected multi-tethered, optically pure 2-ketopiperazine, diketopiperazine, 2-ketodiazepane and 3-aminopyrrolidone scaffolds for Fmoc combinatorial chem. has been developed. It utilizes accessible chiral amino acid precursors, sequentially applying reductive alkylation, dipeptide coupling and regioselective ring formation as key steps. These scaffolds are expansion of our “pool of privileged building blocks” and can introduce valuable drug-like properties in three independent directions to any medicinally relevant piperazine-, diazepane- and pyrrolidone-based motif by “around-the-scaffold” drug optimization. The synthetic routes reported in this work are general and applicable for the preparation of a diverse library of scaffolds, controlling chirality, arm position and length as well as the nature of functional moieties at the arms for further diversification in three independent directions. In addition, these building blocks have a wide application scope in managing fast and efficient multi-cyclic optimization processes in the combinatorial chem. and drug design fields. The experimental process involved the reaction of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate(cas: 53838-27-0).Related Products of 53838-27-0
The Article related to ketopiperazine diketopiperazine ketodiazepane aminopyrrolidone protected enantiopure preparation peptidomimetic, amino acid reductive alkylation dipeptide coupling regioselective cyclization and other aspects.Related Products of 53838-27-0
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