Wang, Anzhu; Zhao, Wei; Yan, Kaituo; Huang, Pingping; Zhang, Hongwei; Ma, Xiaochang published the artcile< Preclinical evidence of paeoniflorin effectiveness for the management of cerebral ischemia/reperfusion injury: a systematic review and meta-analysis>, Electric Literature of 112-63-0, the main research area is meta analysis cerebral ischemia reperfusion injury paeoniflorin; animal studies; cerebral ischemia-reperfusion injury; paeoniflorin; potential mechanisms; preclinical evidence.
Meta-anal. of vessel recanalization is the main treatment for ischemic stroke; however, not all patients benefit from it. This lack of treatment benefit is related to the accompanying ischemia-reperfusion (I/R) injury. Therefore, neuroprotective therapy for I/R Injury needs to be further studied. Paeonia lactiflora Pall. is a commonly used for ischemic stroke management in traditional Chinese medicine; its main active ingredient is paeoniflorin (PF). We aimed to determine the PF’s effects and the underlying mechanisms in instances of cerebral I/R injury. We searched seven databases from their inception to July 2021.SYRCLE’s risk of bias tool was used to assess methodol. quality. Review Manager 5.3 and STATA 12.0 software were used for meta-anal. Thirteen studies, including 282 animals overall, were selected. The meta-analyses showed compared to control treatment, PF significantly reduced neurol. severity scores, cerebral infarction size, and brain water content (p = 0.000). In the PF treatment groups, the apoptosis cells and levels of inflammatory factors (IL-1β) decreased compared to those in the control groups (p = 0.000). Our results suggest that PF is a promising therapeutic for cerebral I/R injury management. However, to evaluate the effects and safety of PF in a more accurate manner, addnl. preclin. studies are necessary.
Frontiers in Pharmacology published new progress about Apoptosis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.
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