Kochetkov, Sergei V.; Kucherenko, Alexander S.; Zlotin, Sergei G. published the artcile< Asymmetric synthesis of warfarin and its analogs catalyzed by C2-symmetric squaramide-based primary diamines>, Formula: C19H34O2, the main research area is squaramide primary diamine preparation reusable; hydroxycoumarin unsaturated ketone squaramide catalyst enantioselective Michael reaction.
Novel C2-sym. N,N’-bis(2-amino-1,2-diphenylethyl)squaramides with 1,2-di(pyridin-2-yl)ethane and 1,2-diphenylethane spacer groups were designed and applied as organocatalysts in asym. additions of 4-hydroxycoumarin and 4-hydroxy-6-methyl-2H-pyran-2-one to α,β-unsaturated ketones. Both enantiomers of the anticoagulant warfarin and its analogs were prepared in up to 96% yield and with 96% ee. Recyclability of the developed catalysts and synthetic utility of the prepared Michael adducts for asym. synthesis of potential chiral medications via acylation reactions were demonstrated.
Organic & Biomolecular Chemistry published new progress about Acylation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics