Sun, Qi; Zhang, Xin-Peng; Duan, Xiu; Qin, Long-Zhou; Yuan, Xin; Wu, Meng-Yu; Liu, Jie; Zhu, Shan-Shan; Qiu, Jiang-Kai; Guo, Kai published the artcile< Photoinduced Merging with Copper- or Nickel-Catalyzed 1,4-Cyanoalkylarylation of 1,3-Enynes to Access Multiple Functionalizatized Allenes in Batch and Continuous Flow>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is functionalized tetrasubstituted allene chemoselective regioselective diastereoselective preparation; enyne cyclobutanone oxime phenylboronic acid cyanoalkylarylation photoredox nickel catalysis.
A three-component reaction of 1,3-enynes and cyclobutanone oxime esters in the presence of phenylboronic acids or organozinc reagents via the photoredox/copper or photoredox/nickel catalysis was established. This redox-neutral 1,4-cyanoalkylarylation reaction was demonstrated mild condition, high catalytic reactivity and wide functional group compatibility, allowing access to a variety of functionalized tetra-substituted allene derivatives I [R1 = H, Me, Ph; R2 = cyclopropyl, n-Bu, Ph, etc.; R3 = H, Ph, OBn, etc.; R4 = H, Me; R5 = H, Et, Bn, etc.; Ar = C6H5, 2-MeC6H4, 3-BrC6H4, etc.] with high chemo- and regioselectivity. Moreover, using photocatalytic continuous flow technique to promote this process would result in increased yields (70% in flow vs. 61% in batch), reduced reaction times (7 min in flow vs. 6 h in batch), and easy scale-up (upgrade to gram scale), showcasing its potential as a synthetic platform.
Chinese Journal of Chemistry published new progress about Alkenynes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics