Hafner, Andreas; Filipponi, Paolo; Piccioni, Lorenzo; Meisenbach, Mark; Schenkel, Berthold; Venturoni, Francesco; Sedelmeier, Joerg published the artcile< A Simple Scale-up Strategy for Organolithium Chemistry in Flow Mode: From Feasibility to Kilogram Quantities>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is scale strategy organolithium chem feasibility kilogram.
A platform for conducting organolithium chem. in continuous flow mode, covering the scales from medicinal chem. to later phase process development, is described. The use of this flow setup, which mimics the concept of flash chem. on scale, was demonstrated by the exemplary, large-scale preparation of (4-fluoro-2-(trifluoromethyl)phenyl)boronic acid following a reaction sequence of halogen/lithium exchange, borylation, and semibatch workup. Also, the key factors and corresponding practical assessments required for the streamlined and seamless scale-up from laboratory environment to higher productivity are highlighted.
Organic Process Research & Development published new progress about Apparatus. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics