Cheng, Jiajia; Huang, Zhijian; Chi, Yonggui Robin published the artcile< NHC Organocatalytic Formal LUMO Activation of α,β-Unsaturated Esters for Reaction with Enamides>, Application of C19H34O2, the main research area is ester unsaturated enantioselective addition rearrangement imine carbene catalyst enamide; pyridinone dihydro asym synthesis; LUMO activation; N-heterocyclic carbenes; esters; lactams; organocatalysis.
Stable α,β-unsaturated esters, e.g. R1CH:CHCO2R2 (R1 = Me, Et, Ph, 4-MeC6H4, 1-naphthyl, 2-thienyl, etc.; R2 = 4-O2NC6H4), were activated by the addition of a chiral N-heterocyclic carbene organocatalyst, and the resulting Michael acceptor intermediates readily reacted with enamide nucleophiles, generated in situ from the corresponding ketone-derived imines, e.g. R3CH2CR4:NTs (R3 = H, Me, n-Pr, H2C:CHCH2; R4 = Ph, 4-FC6H4, 2-naphthyl, 2-thienyl, etc.), to furnish optically active dihydropyridinones, e.g. I. The products can be converted into bioactive δ-lactams, piperidines and their derivatives
Angewandte Chemie, International Edition published new progress about Enantioselective synthesis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics