Wang, Congxiao; Liu, Chao; Chen, Jun; Jiang, Han; Zhang, Wei; Yang, Lili; Li, Xueda; Li, Zixiang; Peng, Lijing; Hu, Xiaokun; Sun, Peng published the artcile< Effect of neoadjuvant iodine-125 brachytherapy upon resection of glioma>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is neoadjuvant iodine125 brachytherapy glioma resection; Combination therapy; Glioma; Neoadjuvant 125I brachytherapy; Surgical resection; Tumor shrinkage.
A more extensive surgical resection of glioma contributes to improved overall survival (OS) and progression-free survival (PFS). However, some patients miss the chance of surgical resection when the tumor involves critical structures. The present study aimed to assess the feasibility of neoadjuvant 125I brachytherapy followed by total gross resection for initially inoperable glioma. Six patients diagnosed with inoperable glioma due to invasion of eloquent areas, bihemispheric diffusion, or large tumor volume received 125I brachytherapy. Surgical resection was performed when the tumor shrank, allowing a safe resection, assessed by the neurosurgeons. Patients were followed up after surgery. Shrinkage of the tumor after adjuvant 125I brachytherapy enabled a total gross resection of all six patients. Four patients were still alive at the last follow-up, with the longest survival time of more than 50 mo, two of which returned to everyday life with a KPS of 100. Another two patients had neurol. injuries with KPSs of 80 and 50, resp. One patient with grade II glioma died 34 mo, and another with grade IV glioma died 40 mo after the combined therapy. In the present study, the results demonstrated that 125I brachytherapy enabled a complete resection of patients with initially unresectable gliomas. The 125I brachytherapy may offer a proper neoadjuvant therapy method for glioma.
BMC Cancer published new progress about Brachytherapy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.
Referemce:
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