Huang, Jiayi; Cui, Yahua; Yang, Yanling; Li, Huahua; Zhang, Yi; Yang, Haiju; Du, Shouying; Bai, Jie published the artcile< Optical Coherence Tomography and Microdialysis for Microneedle-Mediated Penetration Enhancement Study of Paeoniflorin-Loaded Ethosomes>, Reference of 112-63-0, the main research area is microneedle penetration paeoniflorin ethosome; Ethosome; Microdialysis; Microneedle; Optical coherence tomography; Pharmacokinetics.
This paper uses microdialysis to systematically study the percutaneous pharmacokinetics of paeoniflorin-loaded ethosomes. First, optical coherence tomog. (OCT) was used to study the effectiveness of microneedle puncture. Second, a microdialysis method and a UPLC-MS method for determining the amount of paeoniflorin (Pae) in dialyzate were established. Finally, the transdermal pharmacokinetics of TGP-E was studied using in vivo microdialysis in rats under the above MN-assisted conditions. The optimal MN-assisted conditions were obtained at a microneedle length of 500μm, a pressure of 3 N, and an action time of 3 min. The pharmacokinetic results demonstrated that the maximum drug concentration (Cmax) and the area under the curve (AUC) of the TGP-E gel were higher than the TGP-saline solution gel, and the mean retention time was lower. These indicated that microneedle can promote the entry of the ethosomes into the skin for in vivo experiments and greatly improve the possibility of deep penetration of the water-soluble Pae. Therefore, the microneedle-ethosomes delivery system is a more ideal means for promoting the deep penetration of Pae. These findings may provide a reference for the combination of multiple penetration-enhancement ways to promote drug absorption, and also provide a new insight to realize the development of novel, safe, and more effective dosage forms and administration routes of drugs.
Skin Pharmacology and Physiology published new progress about Absorption. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.
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