Wang, Xuewen; Cai, Changqing; Liang, Qichang; Xia, Meng; Lai, Lihua; Wu, Xia; Jiang, Xiaoyun; Cheng, Hao; Song, Yinjing; Zhou, Qiang published the artcile< Integrated transcriptomics and metabolomics analyses of stress-induced murine hair follicle growth inhibition>, Application of C19H34O2, the main research area is hair follicle growth inhibition psychol stress transcriptome metabolome; chronic restraint stress; hair growth inhibition; hexokinase-1; metabolomics; transcriptomics.
Psychol. stress plays an important role in hair loss, but the underlying mechanisms are not well-understood, and the effective therapies available to regrow hair are rare. In this study, we established a chronic restraint stress (CRS)-induced hair growth inhibition mouse model and performed a comprehensive anal. of metabolomics and transcriptomics. Metabolomics data anal. showed that the primary and secondary metabolic pathways, such as carbohydrate metabolism, amino acid metabolism, and lipid metabolism were significantly altered in skin tissue of CRS group. Transcriptomics anal. also showed significant changes of genes expression profiles involved in regulation of metabolic processes including arachidonic acid metabolism, glutathione metabolism, glycolysis gluconeogenesis, nicotinate and nicotinamide metabolism, purine metabolism, retinol metabolism and cholesterol metabolism Furthermore, RNA-Seq analyses also found that numerous genes associated with metabolism were significantly changed, such as Hk-1, in CRS-induced hair growth inhibition. Overall, our study supplied new insights into the hair growth inhibition induced by CRS from the perspective of integrated metabolomics and transcriptomics analyses.
Frontiers in Molecular Biosciences published new progress about Amino acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study) (biosynthesis). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics