Todoriki, Sota; Hosoda, Yui; Yamamoto, Tae; Watanabe, Mayu; Sekimoto, Akiyo; Sato, Hiroshi; Mori, Takefumi; Miyazaki, Mariko; Takahashi, Nobuyuki; Sato, Emiko published the artcile< Methylglyoxal Induces Inflammation, Metabolic Modulation and Oxidative Stress in Myoblast Cells>, HPLC of Formula: 112-63-0, the main research area is metabolome methylglyoxal Murf1 ATP Nqo1 PPARA inflammation oxidative stress; chronic kidney disease; metabolic alteration; methylglyoxal; myoblast cell; sarcopenia.
Uremic sarcopenia is a serious clin. problem associated with phys. disability and increased morbidity and mortality. Methylglyoxal (MG) is a highly reactive, dicarbonyl uremic toxin that accumulates in the circulatory system in patients with chronic kidney disease (CKD) and is related to the pathol. of uremic sarcopenia. The pathophysiol. of uremic sarcopenia is multifactorial; however, the details remain unknown. We investigated the mechanisms of MG-induced muscle atrophy using mouse myoblast C2C12 cells, focusing on intracellular metabolism and mitochondrial injury. We found that one of the causative pathol. mechanisms of uremic sarcopenia is metabolic flow change to fatty acid synthesis with MG-induced ATP shortage in myoblasts. Evaluation of cell viability revealed that MG showed toxic effects only in myoblast cells, but not in myotube cells. Expression of mRNA or protein anal. revealed that MG induces muscle atrophy, inflammation, fibrosis, and oxidative stress in myoblast cells. Target metabolomics revealed that MG induces metabolic alterations, such as a reduction in tricarboxylic acid cycle metabolites. In addition, MG induces mitochondrial morphol. abnormalities in myoblasts. These changes resulted in the reduction of ATP derived from the mitochondria of myoblast cells. Our results indicate that MG is a pathogenic factor in sarcopenia in CKD.
Toxins published new progress about Atrogin 1 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.
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