Koring, Laura; Sitte, Nikolai A.; Bursch, Markus; Grimme, Stefan; Paradies, Jan published the artcile< Hydrogenation of Secondary Amides using Phosphane Oxide and Frustrated Lewis Pair Catalysis>, Quality Control of 112-63-0, the main research area is secondary amine preparation; amide hydrogenation phosphine oxide catalyst frustrated Lewis pair; carboxylic amide; frustrated Lewis pair; hydrogen; hydrogenation; phosphane oxide.
The metal-free catalytic hydrogenation of secondary amides for synthesis of amines RCH2NHR1 [R = i-Pr, Ph, 4-BrC6H4, etc.; R1 = Me, Et, Ph, etc.] was developed. The reduction was realized by two new catalytic reactions. First, the amide was converted into the imidoyl chloride by triphosgene (CO(OCCl3)2) using novel phosphorus(V) catalysts. Second, the in situ generated imidoyl chlorides were hydrogenated in high yields by an FLP-catalyst. Mechanistic and quantum mech. calculations supported an autoinduced catalytic cycle for the hydrogenation with chloride acting as unusual Lewis base for FLP-mediated H2-activation.
Chemistry – A European Journal published new progress about Amides, secondary Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.
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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics