Yu, Jin-Sheng; Zhou, Feng; Liu, Yun-Lin; Zhou, Jian published the artcile< Organocatalytic asymmetric Michael addition of unprotected 3-substituted oxindoles to 1,4-naphthoquinone>, HPLC of Formula: 112-63-0, the main research area is indole quaternary stereogenic center preparation enantioselective synthesis; organocatalyst asym Michael addition oxindole naphthoquinone; 3,3-disubstituted oxindoles; Michael addition; organocatalysis; quaternary stereogenic center; unprotected 3-substituted oxindoles.
The authors reported the first example of an organocatalytic Michael addition of unprotected 3-prochiral oxindole derivatives to 1,4-naphthoquinone. A quinidine derivative (DHQD)2PYR was found to catalyze this reaction in up to 83% ee, with moderate to excellent yields. This method could be used for the synthesis of enantioenriched 3,3-diaryloxindole derivatives, the catalytic synthesis of which was unprecedented. The synthesis of the target compound was achieved using 1,3-dihydro-2H-indol-2-one derivatives and 1,4-naphthalenedione as starting materials. The title compounds thus formed included a 2-(2-oxo-3-indolyl)-1,4-naphthalenedione derivative (I) and related substances.
Beilstein Journal of Organic Chemistry published new progress about Enantioselective synthesis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.
Referemce:
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