Ma, Zhiwei; Liu, Zhijing; Wang, Chuanchuan; Chen, Xiaopei; Tao, Jingchao; Lv, Quanjian published the artcile< A novel isosteviol-based bifunctional squaramide organocatalyst for enantioselective Michael addition of acetylacetone to nitroolefins>, Category: esters-buliding-blocks, the main research area is nitroalkane preparation enantioselective; diketone nitroolefin Michael addition bifunctional squaramide catalyst; Michael addition; acetylacetone; nitroolefin; organocatalysis; tertiary amine-squaramide.
In this study, novel chiral tertiary amine-squaramide I derived from the natural product of the stevioside was developed and applied into the asym. Michael addition of acetylacetones RC(O)CH2C(O)R1 (R = R1 = Me, Ph) to nitroolefins (E)-R2CH=CHNO2 (R2 = naphthalen-1-yl, 4-chlorophenyl, 2-furanyl, etc.). This asym. reaction performed well, and a series of enantiomerically enriched compounds (S/R)-RC(O)CH(CH(R2)CH2NO2)C(O)R1 were obtained in high yields (up to 96%) with excellent enantioselectivities (up to 99% ee).
Chirality published new progress about Alkanes, nitro Role: SPN (Synthetic Preparation), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics