Ohkuma, Takeshi; Kurono, Nobuhito; Sakaguchi, Yusuke; Yamauchi, Kohei; Yurino, Taiga published the artcile< Enantioselective Cyanosilylation of Alkynyl Ketones Catalyzed by Combined Systems Consisting of Chiral Ruthenium(II) Complex and Lithium Phenoxide>, SDS of cas: 112-63-0, the main research area is ketone alkynyl cyanotrimethylsilane ruthenium complex lithium cyanosilylation catalyst; alkynyl tertiary cyanohydrin silyl ether stereoselective preparation.
Asym. cyanosilylation of alkynyl ketones with the catalyst systems consisting of amino acid/2,2′-bis(diphenylphosphino)-1,1′-binaphthyl (BINAP)/ruthenium(II) complex and lithium phenoxide (Ru·Li cat.) was studied. The reaction was conducted in tert-Bu Me ether (TBME) at -78 °C with a substrate-to-catalyst molar ratio (S/C) as high as 2000. A series of simple and functionalized ketones was converted into the alkynyl tertiary cyanohydrin derivatives in up to 99% ee. Appropriate selection of an amino-acid ligand of the catalyst according to the substrate structure was crucially important to achieve high enantioselectivity and a wide scope of substrates. Transformation of the chiral cyanohydrin product into a functionalized lactone was also examined
Advanced Synthesis & Catalysis published new progress about Alkoxysilanes Role: SPN (Synthetic Preparation), PREP (Preparation) (alkynyl tertiary cyanohydrin). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.
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