Tian, Heng-Zhi; Tang, Qing-Gang; Lin, Guo-Qiang; Sun, Xing-Wen published the artcile< Asymmetric synthesis of chiral 1,2-oxazinane and hexahydropyridazine spirocyclic scaffolds by organocatalytic [4 + 2] cycloaddition>, SDS of cas: 112-63-0, the main research area is indolinone alkoxycarbonylmethylene diastereoselective enantioselective cycloaddition unsaturated ester hydrazide; oxazinane spiro oxindole asym synthesis; pyridazinone spiro oxindole asym synthesis.
A novel approach to synthesize chiral 1,2-oxazinane spirocyclic scaffolds I (X = O; Y = H2; R1 = H, 5-MeO, 6-Br, 7-F, etc.; R2 = Me, Et, t-Bu, PhCH2; R3 = Boc, Cbz; R4 = Et; R5 = Ac, Boc, PhCO) by organocatalytic [4 + 2] cycloaddition reaction between methyleneindolinones II and γ-aminooxy-α,β-unsaturated esters EtO2CCH:CHCH2ONHR5 has been developed. Furthermore, a hydrazide 1,4-synthon PhCH2NHNHC(O)CH:CHCO2R4 (R4 = Me, Et, n-Bu) was designed and synthesized to construct the corresponding chiral hexahydropyridazine spirocyclic scaffolds I (X = NH; Y = O; R3 = Boc; R5 = PhCH2) via [4 + 2] cycloaddition reaction with methyleneindolinones II. Both reactions gave the corresponding products in good to excellent yields, excellent diastereoselectivity and good enantioselectivity.
RSC Advances published new progress about [4+2] Cycloaddition reaction (stereoselective). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics