Garcia-Padilla, Carlos; Lozano-Velasco, Estefania; Munoz-Gallardo, Maria del Mar; Castillo-Casas, Juan Manuel; Cano-Carrillo, Sheila; Martinez-Amaro, Francisco Jose; Garcia-Lopez, Virginio; Aranega, Amelia; Franco, Diego; Garcia-Martinez, Virginio; Lopez-Sanchez, Carmen published the artcile< LncRNA H19 Impairs Chemo and Radiotherapy in Tumorigenesis>, Application In Synthesis of 112-63-0, the main research area is review tumorigenesis LncRNA H19 impair chemotherapy radiotherapy; chemo-resistance; lncRNA H19; radio-resistance; tumorigenesis.
A review. Various treatments based on drug administration and radiotherapy have been devoted to preventing, palliating, and defeating cancer, showing high efficiency against the progression of this disease. Recently, in this process, malignant cells have been found which are capable of triggering specific mol. mechanisms against current treatments, with neg. consequences in the prognosis of the disease. It is therefore fundamental to understand the underlying mechanisms, including the genes-and their signaling pathway regulators-involved in the process, in order to fight tumor cells. Long non-coding RNAs, H19 in particular, have been revealed as powerful protective factors in various types of cancer. However, they have also evidenced their oncogenic role in multiple carcinomas, enhancing tumor cell proliferation, migration, and invasion. In this review, we analyze the role of lncRNA H19 impairing chemo and radiotherapy in tumorigenesis, including breast cancer, lung adenocarcinoma, glioma, and colorectal carcinoma.
International Journal of Molecular Sciences published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.
Referemce:
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Ester – an overview | ScienceDirect Topics