Ruff, Yves; Martinez, Roberto; Pelle, Xavier; Nimsgern, Pierre; Fille, Pascale; Ratnikov, Maxim; Berst, Frederic published the artcile< An Amphiphilic Polymer-Supported Strategy Enables Chemical Transformations under Anhydrous Conditions for DNA-Encoded Library Synthesis>, Application of C19H34O2, the main research area is amphiphilic polymer chem transformation anhydrous DNA library; DNA-encoded libraries; decarboxylative coupling; drug discovery; encoded library technologies; solid-supported synthesis.
The use of DNA-encoded libraries has emerged as a powerful hit generation technol. Combining the power of combinatorial chem. to enumerate large compound collections with the efficiency of affinity selection in pools, the methodol. makes it possible to interrogate vast chem. space against biol. targets of pharmaceutical relevance. Thus, the chem. transformations employed for the synthesis of encoded libraries play a crucial role in the identification of diverse and drug-like starting points. Currently established transformations have mostly been limited to water-compatible reactions to accommodate the growing oligonucleotide tag. Herein, we describe the development of a practical catch-and-release methodol. utilizing a cationic, amphiphilic PEG-based polymer to perform chem. transformations on immobilized DNA conjugates under anhydrous conditions. We demonstrate the usefulness of our APTAC (amphiphilic polymer-facilitated transformations under anhydrous conditions) approach by performing several challenging transformations on DNA-conjugated small mols. in pure organic solvents: the addition of a carbanion equivalent to a DNA-conjugated ketone in THF, the synthesis of saturated heterocycles using the tin (Sn) amine protocol (SnAP) in dichloromethane, and the dual-catalytic (Ir/Ni) metallaphotoredox decarboxylative cross-coupling of carboxylic acids to DNA-conjugated aryl halides in DMSO. In addition, we demonstrate the feasibility of the latter in multititer-plate format.
ACS Combinatorial Science published new progress about Immobilization, molecular. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.
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