Park, Hye-Rin; Choi, Hee-Jung; Kim, Bo-Sung; Chung, Tae-Wook; Kim, Keuk-Jun; Joo, Jong-Kil; Ryu, Dongryeol; Bae, Sung-Jin; Ha, Ki-Tae published the artcile< Paeoniflorin enhances endometrial receptivity through leukemia inhibitory factor>, Synthetic Route of 112-63-0, the main research area is endometrial receptivity leukemia inhibitory factor paeoniflorin; embryo implantation; endometrial receptivity; leukemia inhibitory factor; paeoniflorin.
Despite advances in assisted reproductive technol., treatment for deficient endometrial receptivity is a major clin. unmet need. In our previous study, the water extract of Paeonia lactiflora Pall. enhanced endometrial receptivity in vitro and in vivo via induction of leukemia inhibitory factor (LIF), an interleukin (IL)-6 family cytokine. In the present study, we found that paeoniflorin, a monoterpene glycoside, is the major active compound of P. lactiflora. Paeoniflorin significantly improved the embryo implantation rate in a murine model of mifepristone (RU486)-induced implantation failure. In addition, paeoniflorin increased the adhesion of human trophectoderm-derived JAr cells to endometrial Ishikawa cells through the expression of LIF in vitro. Moreover, using the National Center for Biotechnol. Information (NCBI) Gene Expression Omnibus (GEO) database of the human endometrium, we confirmed that LIF signaling is a key regulator for improving human endometrial receptivity. Therefore, these results suggest that paeoniflorin might be a potent drug candidate for the treatment of endometrial implantation failure by enhancing endometrial receptivity..
Biomolecules published new progress about Cell adhesion. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.
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