Zhao, Mingming; Yang, Bin; Li, Liusheng; Si, Yuan; Chang, Meiying; Ma, Sijia; Li, Ronghai; Wang, Yuejun; Zhang, Yu published the artcile< Efficacy of Modified Huangqi Chifeng decoction in alleviating renal fibrosis in rats with IgA nephropathy by inhibiting the TGF-β1/Smad3 signaling pathway through exosome regulation>, COA of Formula: C19H34O2, the main research area is IgA nephropathy exosome Huangqi Chifeng decoction TGFbeta1 Smad3 signaling; Exosomes; IgA nephropathy; Modified Huangqi Chifeng decoction; Renal fibrosis; TGF-β1/Smad3 signaling pathway.
IgA nephropathy is the most common form of primary glomerulonephritis and is a major cause of renal failure worldwide. Modified Huangqi Chifeng decoction (MHCD), a traditional Chinese herbal preparation, has clin. efficacy in reducing the 24-h urine protein levels in patients with IgA nephropathy. However, the mol. mechanism of MHCD needs further study. This study aimed to investigate the mechanisms by which MHCD treatment alleviates renal fibrosis. An IgA nephropathy rat model was established using bovine serum albumin, carbon tetrachloride, and lipopolysaccharide. The rats were divided into control, model, telmisartan, low-dose MHCD, medium-dose MHCD, and high-dose MHCD groups. Treatments were administered to these groups for 8 wk. Subsequently, the 24-h urine protein, serum creatinine, blood urea nitrogen, and blood albumin levels were measured. Pathol. changes and degree of fibrosis in renal tissues were observed, and levels of the transforming growth factor-β1 (TGF-β1)/Smad3 signaling pathway components in renal tissues and TGF-β1 in urinary exosomes were measured. Telmisartan and MHCD reduced 24-h urine protein levels, alleviated renal pathol. injury, and decreased the renal expression of fibronectin, laminin, and collagen IV in rats with IgA nephropathy. Urinary exosomes were extracted and identified for further investigation of their role in renal fibrosis. MHCD reduced TGF-β1 expression in urinary exosomes and reduced TGF-β1 and p-Smad3 levels in renal tissues. MHCD alleviated renal fibrosis in rats with IgA nephropathy by inhibiting the TGF-β1/Smad3 signaling pathway through the downregulation of TGF-β1 expression in exosomes.
Journal of Ethnopharmacology published new progress about Autoimmune glomerulonephritis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.
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