Synthetic Route of 103-26-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 103-26-4, name is Methyl cinnamate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
1,8-Diazabicyclo[5.4.0]undec-7-ene (0.28 ml, 1.85 mmol, 3.0 eq) wasadded to a solution of (E)-3-Phenyl-acrylic acid methyl ester (100 mg, 0.62mmol, 1.0 eq) in methanol (0.35 mL). The resulting solution was stirred at roomtemperature and hydroxylamine in aqueous solution 50% (0.38 ml, 6.17 mmol, 10.0eq) was added. After 30 minutes the reaction was stopped and purified bypreparative HPLC to afford (E)-N-Hydroxy-3-phenyl-acrylamide(92 mg, 0.56 mmol, 91%) as an off-whitesolid: MS ES+ m/z 164.35(M+H)+; 1H NMR (400 MHz, DMSO-d6) delta 10.67 (s, 1H), 7.56 (d, J = 7.2 Hz, 2H), 7.48(d, J = 15.8 Hz, 1H), 7.44 – 7.30 (m, 3H), 6.51 (d, J = 15.8 Hz,1H) ; 13C NMR (101 MHz, DMSO-d6) delta 163.0, 138.6, 135.0, 129.7, 129.1, 127.7, 119.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl cinnamate, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Beillard, Audrey; Bhurruth-Alcor, Yushma; Bouix-Peter, Claire; Bouquet, Karinne; Chambon, Sandrine; Clary, Laurence; Harris, Craig S.; Millois, Corinne; Mouis, Gregoire; Ouvry, Gilles; Pierre, Romain; Reitz, Arnaud; Tomas, Loic; Tetrahedron Letters; vol. 57; 20; (2016); p. 2165 – 2170;,
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