Sander, Kerstin; Gendron, Thibault; Yiannaki, Elena; Cybulska, Klaudia; Kalber, Tammy L.; Lythgoe, Mark F.; Arstad, Erik published the artcile< Sulfonium Salts as Leaving Groups for Aromatic Labelling of Drug-like Small Molecules with Fluorine-18>, HPLC of Formula: 112-63-0, the main research area is pharmacokinetics sulfonium salt small mol fluorine 18 immunolabeling bioimaging.
Positron emission tomog. (PET) is unique in that it allows quantification of biochem. processes in vivo, but difficulties with preparing suitably labeled radiotracers limit its scientific and diagnostic applications. Aromatic [18F]fluorination of drug-like small mols. is particularly challenging as their functional group compositions often impair the labeling efficiency. Herein, we report a new strategy for incorporation of 18F into highly functionalized aromatic compounds using sulfonium salts as leaving groups. The method is compatible with pharmacol. relevant functional groups, including aliphatic amines and basic heterocycles. Activated substrates react with [18F]fluoride at room temperature, and with heating the reaction proceeds in the presence of hydrogen bond donors. Furthermore, the use of electron rich spectator ligands allows efficient and regioselective [18F]fluorination of non-activated aromatic moieties. The method provides a broadly applicable route for 18F labeling of biol. active small mols., and offers immediate practical benefits for drug discovery and imaging with PET.
Scientific Reports published new progress about Biological uptake. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics