Melnick, Kaitlyn F.; Miller, Patricia; Carmichael, Ethan; McGrath, Kyle; Ghiaseddin, Ashley; Tran, David D.; Rahman, Maryam published the artcile< The trial effect in patients with glioblastoma: effect of clinical trial enrollment on overall survival>, Application of C19H34O2, the main research area is Clinical Trial; Glioblastoma; Glioma; Neuro-oncology.
Abstract: Purpose: To determine whether participation in a clin. trial was associated with improved survival in patients with glioblastoma (GBM). Methods: Following IRB approval, patients were identified using CPT and ICD codes. Data was collected using retrospective review of electronic medical records. When necessary, death data was obtained from online obituaries. Inverse propensity score matching was utilized to transform the two cohorts to comparable sets. Survival was compared using Kaplan-Meyer curves and Wilcoxon Rank Sum Test. Results: In this cohort of 365 patients, 89 were enrolled in a clin. trial and 276 were not. Patients enrolled in clin. trials had a significantly higher mean baseline KPS score, higher proportion of surgical resections, and were more likely to receive temozolomide treatment than patients not enrolled in a clin. trial. After inverse propensity score matching, patients enrolled in a clin. trial lived significantly longer than those not enrolled (28.8 vs 22.2 mo, p = 0.005). A potential confounder of this study is that patients not in a clin. trial had significantly fewer visits with neuro-oncologists than patients enrolled in a clin. trial (7 ± 8 vs 12 ± 9, p < 0. 0001). Conclusions: Clin. trials enroll patients with the most favorable prognostic features. Even when correcting for this bias, clin. trial enrollment is an independent predictor of increased survival regardless of treatment arm. Journal of Neuro-Oncology published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.
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