Yang, Wanchun; Yuan, Qiuyun; Zhang, Shuxin; Zuo, Mingrong; Li, Tengfei; Li, Junhong; Zhou, Xingwang; Li, Mao; Feng, Wentao; Xia, Xiaoqiang; Chen, Mina; Liu, Yanhui published the artcile< Elevated GIGYF2 expression suppresses tumor migration and enhances sensitivity to temozolomide in malignant glioma>, Formula: C19H34O2, the main research area is GIGYF2 tumor migration temozolomide malignant glioma.
Glioma is a common type of malignant and aggressive tumor in the brain. Despite progress on mechanistic studies, current understanding of the initiation and progression of glioma remains incomplete. GIGYF2 is a critical regulator in neural development and degeneration, however, its contribution in glioma is not yet elucidated. In this study, using an integrative approach spanning bioinformatic anal. and functional approaches, we explored the potential contribution of GIGYF2 in glioma. Bioinformatic data from public database and our cohort showed that GIGYF2 expression was closely associated with low glioma malignancy and better patient survival. Elevation of GIGYF2 expression impaired cell migration and enhanced temozolomide sensitivity of human glioma cells. We further establish its mol. mechanism by demonstrating that GIGYF2 inhibits MMP-9 mediated cell migration pathway and pro-survival AKT/Bax/Caspase-3 signaling. Our work identifies the suppressive role of GIGYF2 in gliomas, and clarifies the relationship between GIGYF2 expression and glioma malignancy, which may provide a potential target for future interventions.
Cancer Gene Therapy published new progress about Animal gene Role: BSU (Biological Study, Unclassified), PRP (Properties), BIOL (Biological Study) (GIGYF2). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.
Referemce:
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Ester – an overview | ScienceDirect Topics