Liu, Li; Tang, Manshu; Walsh, Martin J.; Brimacombe, Kyle R.; Pragani, Rajan; Tanega, Cordelle; Rohde, Jason M.; Baker, Heather L.; Fernandez, Elizabeth; Blackman, Burchelle; Bougie, James M.; Leister, William H.; Auld, Douglas S.; Shen, Min; Lai, Kent; Boxer, Matthew B. published the artcile< Structure activity relationships of human galactokinase inhibitors>, HPLC of Formula: 112-63-0, the main research area is structure galactokinase inhibitor preparation; Galactokinase; Galactosemia; Structure–activity relationships.
Classic galactosemia is a rare inborn error of metabolism that is caused by deficiency of galactose-1-phosphate uridyltransferase (GALT), an enzyme within the Leloir pathway that is responsible for the conversion of galactose-1-phosphate (gal-1-p) and UDP-glucose to glucose-1-phosphate and UDP-galactose. This deficiency results in elevated intracellular concentrations of its substrate, gal-1-p, and this increased concentration is believed to be the major pathogenic mechanism in Classic Galactosemia. Galactokinase (GALK) is an upstream enzyme of GALT in the Leloir pathway and is responsible for conversion of galactose and ATP to gal-1-p and ADP. Therefore, it was hypothesized that the identification of a small-mol. inhibitor of human GALK would act to prevent the accumulation of gal-1-p and offer a novel entry therapy for this disorder. Herein the authors describe a quant. high-throughput screening campaign that identified a single chemotype that was optimized and validated as a GALK inhibitor I.
Bioorganic & Medicinal Chemistry Letters published new progress about Enzyme inhibition kinetics. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics