Mdanda, Sipho; Ntshangase, Sphamandla; Singh, Sanil D.; Naicker, Tricia; Kruger, Hendrik G.; Baijnath, Sooraj; Govender, Thavendran published the artcile< Mass spectrometric investigations into the brain delivery of abacavir, stavudine and didanosine in a rodent model>, Formula: C19H34O2, the main research area is brain abacavir stavudine didanosine drug delivery pharmacokinetics mass spectrometry; HIV neurocognitive disorder; mass spectrometric techniques and central nervous system; nucleoside reverse transcriptase inhibitors.
HIV replication in the brain is unopposed due to reduced antiretroviral drug penetration into the central nervous system (CNS). Prevalence of HIV-associated neurocognitive disorder (HAND) has increased severely in patients living with HIV despite current treatments. The aims of this study were to evaluate the brain bio-distribution of alternative nucleoside reverse transcriptase inhibitors, abacavir, stavudine and didanosine in the CNS and to determine their localization patterns in the brain. Sprague-Dawley rats received 50 mg kg-1 single i.p dose of each drug. Mass spectrometric techniques were then used to investigate the pharmacokinetics and localization patterns of these drugs in the brain using LC-MS/MS and mass spectrometric imaging (MSI), resp. Abacavir, stavudine and didanosine reached the Brain Cmax with concentration of 831.2, 1300 and 43.37 ngmL-1, resp. Based on MSI anal. Abacavir and Stavudine were located in brain regions that are strongly implicated in the progression of HAND. Abacavir and Stavudine penetrated into CNS, reaching a Cmax that was above the IC50 for HIV (457.6 and 112.0 ngmL-1, resp.), however, it was noted ddI showed poor entry within the brain, therefore, it is recommended that this drug cannot be considered for treating CNS-HIV.
Xenobiotica published new progress about Blood plasma. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics