Gaunt, Matthew J.; Jessiman, Alan S.; Orsini, Paolo; Tanner, Huw R.; Hook, David F.; Ley, Steven V. published the artcile< Synthesis of the C-1-C-28 ABCD Unit of Spongistatin 1>, Reference of 617-55-0, the main research area is asym synthesis spongistatin ABCD fragment anti aldol condensation borinate; beta keto dithiane preparation conjugate addition dithiol ynone.
The synthesis of the C-1-C-28 ABCD fragment I of spongistatin 1 is described. Anti-selective boron-mediated aldol coupling of a CD spiroketal ketone fragment II to an AB spiroketal aldehyde unit III forms the desired C1-C28 advanced intermediate I. Other features include the double conjugate addition of a dithiol to an ynone to generate the key β-keto-dithiane unit required for the synthesis of the AB spiroketal fragment.
Organic Letters published new progress about Aldol condensation (anti-selective boron-mediated aldol coupling). 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Reference of 617-55-0.
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