Kamal, Ahmed; Balakrishna, Moku; Reddy, Papagari Venkat; Rahim, Abdul published the artcile< First total synthesis of the E- and Z-isomers of cytospolide-D>, Quality Control of 617-55-0, the main research area is cytospolide D synthesis.
A simple, convergent, and efficient approach for the total synthesis of the bioactive E- and Z-isomers of cytospolide-D is described. The key features of the synthetic strategy include stereoselective methylation, regioselective epoxide opening, olefin cross-metathesis, and a Yamaguchi protocol reaction for the formation of the E-olefinic geometry of the 10 membered ring; Steglich esterification and ring-closing metathesis reaction for the formation of the 10 membered ring with a Z-olefinic geometry in the skeleton. L-Malic acid was used as a chiral pool starting material for the construction of the olefinic acid fragment while D-mannitol was used as a chiral pool starting material for the building of the olefinic alc. fragment.
Tetrahedron: Asymmetry published new progress about Cross-metathesis. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Quality Control of 617-55-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics