Sadeghpour, H.; Jalilian, A. R.; Shafiee, A.; Akhlaghi, M.; Miri, R.; Mirzaei, M. published the artcile< Radiosynthesis of dimethyl-2-[18F]-(fluoromethyl)-6-methyl-4-(2-nitrophenyl)-1,4- dihydropyridine-3,5-dicarboxylate for L-type calcium channel imaging>, Computed Properties of 112-63-0, the main research area is fluorine 19 dimethylfluoromethylmethylnitrophenyl dihydropyridine dicarboxylate radiosynthesis calcium channel imaging.
Di-Me 2-(fluoromethyl)-6-methyl-4-(2-nitrophenyl)-1,4-dihydropyridine- 3,5-dicarboxylate 4a, a fluorinated nifedipine analog, has been shown to elicit significant calcium channel blocker activity using a guinea pig ileal longitudinal smooth muscle model. In order to perform biol. studies for detection of L-type calcium channel distribution, we decided to prepare the [18F]-labeled compound The latter compound was prepared in no-carrier-added (n.c.a.) form from di-Me 2-(bromomethyl)-6-methyl-4-(2-nitrophenyl)-1,4-dihydropyridine- 3,5-dicarboxylate 2 in one step at 80°C in Kryptofix[222]/K[18F]F and acetonitrile as a solvent in 15 min. Column chromatog. afforded the radiochem. pure compound in 20 min. Radiochem. purity of the 18F-nifedipine was determined by RTLC and HPLC (> 98%) and specific activity of 21-48 GBq/μmol (EOB).
Radiochimica Acta published new progress about Calcium channel blockers. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.
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