Selman, Mohammed; Ou, Paula; Rousso, Christopher; Bergeron, Anabel; Krishnan, Ramya; Pikor, Larissa; Chen, Andrew; Keller, Brian A.; Ilkow, Carolina; Bell, John C.; Diallo, Jean-Simon published the artcile< Dimethyl fumarate potentiates oncolytic virotherapy through NF-κB inhibition>, HPLC of Formula: 112-63-0, the main research area is dimethyl fumarate anticancer antiviral agent NFkappaB breast colon cancer.
Resistance to oncolytic virotherapy is frequently associated with failure of tumor cells to get infected by the virus. Di-Me fumarate (DMF), a common treatment for psoriasis and multiple sclerosis, also has anticancer properties. We show that DMF and various fumaric and maleic acid esters (FMAEs) enhance viral infection of cancer cell lines as well as human tumor biopsies with several oncolytic viruses (OVs), improving therapeutic outcomes in resistant syngeneic and xenograft tumor models. This results in durable responses, even in models otherwise refractory to OV and drug monotherapies. The ability of DMF to enhance viral spread results from its ability to inhibit type I interferon (IFN) production and response, which is associated with its blockade of nuclear translocation of the transcription factor nuclear factor κB (NF-κB). This study demonstrates that unconventional application of U.S. Food and Drug Administration-approved drugs and biol. agents can result in improved anticancer therapeutic outcomes.
Science Translational Medicine published new progress about Adenoviridae. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics