Akiel, Maaged A.; Alshehri, Ohoud Y.; Aljihani, Shokran A.; Almuaysib, Amani; Bader, Ammar; Al-Asmari, Ahmed I.; Alamri, Hassan S.; Alrfaei, Bahauddeen M.; Halwani, Majed A. published the artcile< Viridiflorol induces anti-neoplastic effects on breast, lung, and brain cancer cells through apoptosis>, Application of C19H34O2, the main research area is brain cancer cells anti neoplastic effect breast lung apoptosis; Anticancer; Apoptosis; Natural product; Viridiflorol, Cytotoxicity, Drug discovery.
All active natural mols. are not fully exploited as therapeutic agents, causing delays in the advancement of anticancer drug discovery. Viridiflorol is a natural volatile element that may work as anti-cancer compound We tested the anticancer properties of viridiflorol at different concentrations ranging from 0.03 to 300μM in vitro on three cancer cells including breast (MCF-7), lung (A549) and brain (Daoy). The cancer cells responses were documented after treatment using MTT and Annexin V assays. Viridiflorol showed cytotoxic effects against all tested cell lines, reducing cell viability in a concentration-dependent manner with variable IC50 values. Daoy and A549 cell lines were more sensitive to viridiflorol when compared with temozolomide and doxorubicin, resp. Viridiflorol demonstrated the highest anticancer activity against the Daoy cells with an estimated IC50 of 0.1μM followed by MCF-7 at 10μM, and A549 at 30μM. In addition, upon exposure to concentrations ranging from 30μM to 300μM of viridiflorol, early and late apoptotic cell death was induced in a concentration dependent manner in Daoy (55.8-72.1), MCF-7 (36.2-72.7) and A459 (35-98.9) cell lines, resp. In conclusion, viridiflorol demonstrates cytotoxic and apoptotic ability in three different cancer cell lines (brain, breast and lung).
Saudi Journal of Biological Sciences published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.
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