Taniguchi, Yosuke; Magata, Yuya; Osuki, Takayuki; Notomi, Ryotaro; Wang, Lei; Okamura, Hidenori; Sasaki, Shigeki published the artcile< Development of novel C-nucleoside analogues for the formation of antiparallel-type triplex DNA with duplex DNA that includes TA and dUA base pairs>, COA of Formula: C19H34O2, the main research area is nucleoside DNA duplex triplex association constant.
Expansion of the triplex DNA forming sequence is required in the genomic targeting fields. Basically, triplex DNA is formed by the interaction between the triplex-forming oligonucleotides and homo-purine region with the target duplex DNA. The presence of the base pair conversion sites hampers stable triplex formation. To overcome this limitation, it is necessary to develop an artificial nucleic acid to recognize the base conversion sites, and the CG and TA base pairs. We describe the synthesis of C-nucleoside analogs and an evaluation of the ability of triplex formation. Consequently, the combined use of the novel C-nucleoside analogs, AY – AY-d(Y-NH2), AY-d(Y-Cl) and IAP-d(Y-Cl), is capable of recognizing duplex DNA including the TA or dUA base pair.
Organic & Biomolecular Chemistry published new progress about DNA Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics