Bedford, G. R.; Partridge, M. W. published the artcile< Convenient preparation of ο-aminoaryl cyanides>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is .
ο-Aminophenyl cyanide (I) and the related compounds can be prepared by thermal decomposition of isatin 3-oxime (II) and related isatins in good yield. The method is applicable to the production of substituted ο-aminoaryl cyanides having orientations not readily accessible by methods hitherto used. Decomposition of the oximes is vigorous, and for a 50 g. amount is complete in about 3 min. When no solvent is used, provision must be made to trap the aminoaryl cyanide entrained in the evolved CO2. II (50 g., recrystallized from 50% aqueous alc.) was melted and heated so that I was collected in receivers containing Et2O. Evaporation of the Et2O gave pure I in 65% yield, m. 49-50°; Ac derivative, m. 134°. Similarly 48 g. 5-methylisatin 3-oxime gave 17.6 g. 2-amino-4-methylphenyl cyanide, b15 150-2°, m. 59-60°; 5-chloroisatin 3-oxime (5 g.) decomposed during 15 min. at 250° gave 2 g. 2-amino-5-chlorophenyl cyanide, m. 96-8°; 7-carboxyisatin 3-oxime (5.1 g.) gave 0.62 g. 2-amino-5-cyanobenzoic acid, needles, m. 280-2° (this compound was amphoteric and gave a pos. diazo test); 5-nitroisatin 3-oxime (5 g.) heated 45 min. in refluxing PhNO2 gave 2.6 g. 2-amino-5-nitrophenyl cyanide, m. 205-6°.
Journal of the Chemical Society published new progress about Nitriles Role: BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics