Sheng, Binbin; Xu, Jing; Ge, Yongsheng; Zhang, Shuo; Wang, Danqi; Gao, Chao; Ma, Cuiqing; Xu, Ping published the artcile< Enzymatic Resolution by a D-Lactate Oxidase Catalyzed Reaction for (S)-2-Hydroxycarboxylic Acids>, Related Products of 112-63-0, the main research area is lactate oxidase stereoselective oxidation hydroxycarboxylic acid resolution.
Oxidase-catalyzed kinetic resolution is important for the production of enantiopure 2-hydroxycarboxylic acids (2-HAs), which are versatile building blocks for the synthesis of many significant compounds However, in contrast to that of (R)-2-HAs, the production of (S)-2-HA is challenging because of the lack of related oxidases. Herein, suitable enzymes were screened systematically through the anal. of numerous putative D-lactate oxidase sequences and identification of several required properties. Finally, a D-lactate oxidase from Gluconobacter oxydans 621H with advantageous characteristics, such as good solubility, broad substrate spectrum, and high stereoselectivity, was selected to resolve 2-HAs into (S)-2-HAs. A variety of (S)-2-HAs was produced successfully using this D-lactate oxidase with excellent enantiomeric excess values (>99 %). The presented screening criteria and approach for target biocatalysis suggested a guideline for the production of optically active chems. such as (S)-2-HAs.
ChemCatChem published new progress about Biochemical reaction kinetics. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics