Jamshaid, Sana; Devkota, Shreedhar; Lee, Yong Rok published the artcile< Catalyst- and Substituent-Controlled Regio- and Stereoselective Synthesis of Indolyl Acrylates by Lewis-Acid-Catalyzed Direct Functionalization of 3-Formylindoles with Diazo Esters>, Formula: C11H12O3, the main research area is hydroxy indolyl acrylate preparation diastereoselective regioselective; alkoxy oxoethoxy indolyl acrylate preparation diastereoselective regioselective; formylindole diazo ester addition reaction Lewis Acid catalyst.
A facile and efficient In(OTf)3- and BF3.OEt2-catalyzed direct transformation of 3-formylindoles I (R = Me, prop-2-en-1-yl, Ph, Bn, etc.; R1 = H, Me, Et, Ph; R2 = H, Ph, OBn; R3 = H, Me, Ph, naphthalen-2-yl, etc.; R4 = H, Me, Br, Cl, F; R5 = H, Me; R4R5 = -(CH2)3-, -CH=CH-CH=CH-) with diazo esters N2=CHC(O)OR6 (R6 = Et, allyl, Bn, cyclohexyl, etc.) has been developed for synthesizing diverse and functionalized indolyl acrylates II, III and IV. This one-pot protocol furnishes various (Z)-α-hydroxy-β-indolyl acrylates II, (E)-β-(2-alkoxy-2-oxoethoxy)-α-indolyl acrylates III, and (Z)-3-hydroxy-2-indolyl acrylates IV by a catalyst- and substituent-controlled, regio- and stereoselective cascade reaction. The protocol has several advantages, including low loading of the catalyst, mild reaction conditions, broad scope, and high functional group tolerance. The synthesized compounds II, III and IV can be further converted into diversely functionalized materials.
Organic Letters published new progress about C-H bond activation. 94-02-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H12O3, Formula: C11H12O3.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics