Xu, Yuan; He, Hong; Li, Ping; Liu, Hongwei published the artcile< Paeoniflrin inhibits proliferation and promotes autophagy and apoptosis of sweat gland cells>, Category: esters-buliding-blocks, the main research area is skin disease paeoniflrin sweat gland cell proliferation autophagy apoptosis; autophagy; axillary bromhidrosis; hSGCs; proliferation.
Axillary bromhidrosis is sweat excreted by apocrine glands in the armpits, mouth corners and other parts. The clin. manifestation includes excessive sweating and heavy odor, leading to the growth of bacteria and skin disease. The present study investigated the mechanism underlying the effect of paeoniflrin (PF) in the treatment of bromhidrosis. PF was injected into the feet of rats, and the foot skin was dissected for histol. anal. Primary human sweat gland cells (hSGCs) were isolated from patients with bromhidrosis. After 24 h treatment with PF or 3-methyladenine, the production of reactive oxygen species (ROS), autophagy, apoptosis, proliferation and cell cycle distribution were determined PF induced nuclear pyknosis in rat SGCs. In vitro PF treatment inhibited cell proliferation with a 25% inhibitory concentration of 9.530μM. Treatment with 9.530μM PF for 24 h signifi cantly increased apoptosis, ROS production and autophagy in hSGCs. PF promoted LC3B and Beclin 1 expression, but inhibited p62, phosphorylated (p)-PI3K and p-Akt expression. 3-methyladenine treatment reversed PF-induced changes in hSGCs. PF-induced inhibition of hSGC proliferation was associated with ROS production, apoptosis, and autophagy. These fidings provide a basis for treating bromhidrosis.
Experimental and Therapeutic Medicine published new progress about Apoptosis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.
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