Shi, Jia; Dong, Xuchen; Han, Wei; Zhou, Peng; Liu, Liang; Wang, Haiyang; Jiang, Qianqian; Li, Haoran; Cheng, Shan; Li, Suwen; Yuan, Jiaqi; Qian, Zhiyuan; Dong, Jun published the artcile< Molecular characteristics of single patient-derived glioma stem-like cells from primary and recurrent glioblastoma>, Formula: C19H34O2, the main research area is human glioblastoma glioma stem like temozolomide.
Glioblastoma has high recurrence, while the sensitivity of recurrent glioblastoma to chemotherapy is lower than that of primary glioblastoma. Moreover, there is no standardized treatment for recurrent glioblastoma. Unfortunately, the biol. mechanism of recurrent glioblastoma is still unclear, and there are few related studies. We compared the phenotypes of clin. glioblastoma specimens, in-vitro cultured glioma stem-like cells (GSCs) and patient-derived xenograft tumor (PDX) models to explore the mol. genetic characteristics of primary and recurrent glioblastoma from the same patient. In vitro, SU5-2, GSCs derived from recurrent glioblastoma specimens, had stronger proliferative activity and self-renewal ability. Meanwhile, SU5-2 was more resistant to temozolomide and invasive than SU5-1, which derived from primary glioblastoma specimens. Further anal. of the expression of costimulatory mols. showed that the expression of B7-H1, B7-H2 and B7-H3 of SU5-2 were upregulated. In vivo, Kaplan-Meier survival curve anal. showed that the median survival of the recurrent PDX group was worse. The results of gene detection in vitro, PDX model and clin. samples were consistent. Our results showed that the GSCs based on glioblastoma specimens and the PDX models could replicate the main mol. genetic characteristics of original tumors, which provided a reliable exptl. platform for both tumor translation kinds of research and screening of mol. therapeutic targets.
Anti-Cancer Drugs published new progress about Cell invasion. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.
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