Ding, Yu; Song, Xiuxian; Yu, Zhiming published the artcile< Transcriptome profiles of genes related to growth and virulence potential in Vibrio alginolyticus treated with modified clay>, Category: esters-buliding-blocks, the main research area is Vibrio alginolyticus modified clay growth virulence transcriptome profile gene; Growth; Modified clay; Transcriptome; Vibrio alginolyticus; Virulence.
Vibrio alginolyticus is a globally distributed opportunistic pathogen that causes different degrees of disease in various marine organisms, such as fish, shrimp and shellfish. At present, vibriosis caused by V. alginolyticus has a wide epidemic range and causes frequent outbreaks, resulting in substantial losses in aquaculture. According to previous studies, modified clay (MC) could effectively flocculate and reduce the d. of Vibrio in water, but it is still unknown whether MC inhibits growth and how it affects virulence in bottom flocs. Here, we studied the response mechanism of V. alginolyticus in flocs treated with MC at the transcriptome level and verified the transcriptomic data combined with relevant physiol. experiments and reverse transcription quant. real-time PCR (RT-qPCR) for the first time. It was found that the morphol. of Vibrio in the MC flocs changed, the membrane function was damaged, the antioxidant system was activated, and the material and energy metabolism also changed. In addition, MC could inhibit the expression of virulence factors of V. alginolyticus; for example, flagella, pilus, siderophores, quorum sensing, and other related genes were significantly downregulated. In general, MC effectively inhibited the growth of Vibrio and reduced its virulence potential in flocs, which could provide theor. support for a new model of healthy aquaculture.
Microbiological Research published new progress about Antioxidants. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.
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