Zhou, Jianrong; Hartwig, John F. published the artcile< Intermolecular, Catalytic Asymmetric Hydroamination of Bicyclic Alkenes and Dienes in High Yield and Enantioselectivity>, SDS of cas: 112-63-0, the main research area is alkene diene strained bicyclic enantioselective hydroamination aniline iridium catalyst; norbornane arylamino stereoselective preparation ozonolysis ring opening metathesis; cyclopentane amino stereoselective preparation.
A set of catalytic, intermol. hydroaminations of strained bicyclic olefins and dienes are reported that occur in both high yield and high enantioselectivity. These reactions occur with a catalyst generated from [Ir(cyclooctene)2Cl]2, sterically hindered and electron-rich derivatives of the Segphos (I, R1 = Ph, 3,5-diMeC6H3, 3,5-di-tert-butyl-4-methoxyphenyl) and BIPHEP (II R2 = R1, 3,4,5-trimethoxyphenyl) families of ligands, and a soluble base. This system catalyzes the addition of various anilines to norbornene, norbornadiene, and other bicyclic olefins. The products from addition of p-anisidine can be transformed to BOC-protected norbornylamine and to substituted cyclopentanes in nearly enantiopure form. Mechanistic studies show that addition of aniline-d2 occurs in a syn fashion and suggest that the catalytic cycle comprises oxidative addition of aniline to form a bis-anilide hydride complex, followed by migratory insertion of olefin and reductive elimination of product in a series of steps involving iridium complexes containing ancillary bisphosphine and arylamide ligands.
Journal of the American Chemical Society published new progress about Aromatic amines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics