Zhu, Xing-Li; Xu, Jin-Hui; Cheng, Dao-Juan; Zhao, Li-Jiao; Liu, Xin-Yuan; Tan, Bin published the artcile< In Situ Generation of Electrophilic Trifluoromethylthio Reagents for Enantioselective Trifluoromethylthiolation of Oxindoles>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is trifluoromethylthiolation enantioselective oxindole trifluoromethylthiosilver.
An organocatalytic asym. trifluoromethylthiolation reaction via in situ generation of active electrophilic trifluoromethylthio species involving trichloroisocyanuric acid and AgSCF3 as a practical and easily handled electrophilic SCF3 source for CSP3-SCF3 bond formation was developed. Reactions with this one-pot version strategy occurred in good yields and excellent stereoselectivities to access enantiopure oxindoles bearing a SCF3-substituted quaternary chiral center. E.g., in presence of trichloroisocyanuric acid, AgSCF3, and catalyst (DHQD)2Pyr, trifluoromethylthiolation of oxindole derivative (I) gave 78% II (90 °C). The straightforward process described here makes use of simple starting materials and proceeds under mild conditions, which will be useful in medicinal chem. and diversity-oriented syntheses.
Organic Letters published new progress about Enantioselective synthesis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics