Gangane, Purushottam Shridhar; Pachpute, Tejas; Mahapatra, Debarshi Kar; Mahajan, Nilesh Manoharrao published the artcile< HPMC polymers and xanthan gum assisted development and characterization of stavudine extended release floating tablets>, HPLC of Formula: 112-63-0, the main research area is xanthan gum assisted development extended release floating tablet.
Stavudine has a low half-life of 0.8-1.5 h and therefore needs recurrent administration to sustain stable beneficial drug plasma levels. In order to enhance and preserve the stable drug level of stavudine for round the clock, gastroretentive systems (floating low-d. formulations that cause buoyancy on the gastric fluid in the stomach) may prove to be advantageous for releasing the drug content from the matrix tablet reservoirs for several hours. The current research endeavors towards formulating the stavudine floating tablet formulations (F1-F9) employing rate modifying polymers such as HPMC K15M, xanthan gum and HPMC K100M using multiple punch tablet compression machine containing 9 mm diameter, round flat-faced punches to form 80 mg tablet with a batch size of 100. The drug-polymer compatibility was investigated through Fourier-Transformed IR Spectroscopy (FTIR) and Differential Scanning Calorimetry (DSC). The stavudine floating tablet formulations were successfully fabricated. The pre-compression characteristics (tapped d., bulk d., Hausner’s ratio, Carr’s index and angle of repose) as well as postcompression characteristics (appearance, hardness, dimension, drug content, friability, swelling index, weight variation, in vitro drug release, in vitro buoyancy, accelerated stability and drug release kinetics for 90 days) of the formulations were comprehensively studied. This research study on stavudine will definitely open several new milestones for anti-retroviral pharmacotherapeutics in the upcoming future perspectives by enhancing the half-life of the drug employing the floating extended-release attributes.
Indian Journal of Pharmaceutical Education and Research published new progress about Artificial gastric juice. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics