Han, Chunyu; Tian, Xianhai; Song, Lina; Liu, Yaowen; Hashmi, A. Stephen K. published the artcile< Tetra-substituted furans by a gold-catalysed tandem C(sp3)-H alkynylation/oxy-alkynylation reaction>, Recommanded Product: Ethyl 3-oxo-3-phenylpropanoate, the main research area is THF preparation; ketone hypervalent iodine reagent tandem alkynylation oxyalkynylation.
A gold-catalyzed cascade C(sp3)-H alkynylation/oxy-alkynylation of acceptor-substituted carbonyl compounds with hypervalent iodine(III) reagents for the synthesis of tetra-substituted furans is described. This reaction involves two Au(I)/Au(III) catalytic cycles and proceeds through a C(sp3)-H alkynylation of a substituted ketone and a subsequent oxy-alkynylation of the generated 2-alkynyl ketone. This mild and simple method can tolerate a wide range of functionalities, offering distinct advantages over previous methods using PIDA as the external oxidant. Furthermore, a gram-scale synthesis is feasible and the synthesized furan product was readily transformed into other related compounds
Organic Chemistry Frontiers published new progress about Alkynylation. 94-02-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H12O3, Recommanded Product: Ethyl 3-oxo-3-phenylpropanoate.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics