Yuan, Huijun; Gao, Hua; Liu, Kun; Liu, Zhantao; Wang, Jian; Li, Wenjun published the artcile< Cycloadduct formation of α,β-unsaturated esters with azides catalyzed by NHC systems>, Electric Literature of 112-63-0, the main research area is cycloaddition unsaturated ester azide preparation triazole dihydropyrazole organocatalyst NHC.
1,2,3-Triazoles and aminomethylpyrazoles were prepared by 1,3-cycloaddition of azides with α,β-unsaturated esters organocatalyzed by N-heterocyclic carbenes, formed in situ from imidazolium and 1,2,4-triazolium salts. NHC-catalyzed cycloadduct formation of α,β-unsaturated esters with azides has been developed. This strategy could generate 1,2,3-triazoles and dihydropyrazoles with high yields and regioselectivities in the presence of an N-heterocyclic carbene catalyst. The broad substrate scope and mechanistic survey of this process are also presented.
Organic & Biomolecular Chemistry published new progress about Azides Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics