Hejmanowska, Joanna; Albrecht, Lukasz published the artcile< Organocatalytic asymmetric approach to spirocyclic tetrahydrothiophenes containing either a butenolide or an azlactone structural motif>, Quality Control of 112-63-0, the main research area is spirocyclic tetrahydrothiophene preparation enantioselective; mercaptoacetaldehyde butenolide azlactone Michael addition aldol organocatalyst.
In this manuscript a new organocatalytic approach to spirocyclic tetrahydrothiophenes bearing either a butenolide or an azlactone moiety is described. The developed methodol. is based on the cascade reactivity of 2-mercaptoacetaldehyde (generated in situ from 1,4-dithiane-2,5-diol) with α,β-unsaturated butenolides or azlactones, that consists of a thio-Michael addition followed by an intramol. aldol reaction. Chiral bases derived from cinchona alkaloids are used as a catalyst promoting the cascade and controlling its stereochem. outcome.
ARKIVOC (Gainesville, FL, United States) published new progress about Aldol addition, stereoselective. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.
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